Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN
The Cell Line Explorer App for Neuroblastoma (CLEAN) is now publicly accessible. Jonatan Gabre and colleagues made an interactive web application to facilitate neuroblastoma (NB) research. We aim to make all published NB RNA-Seq and phosphoproteomic dataset readily and easily available for anyone in the field.
Dec 28, 2023
EMBL Cancer Genomics Conference
All lab members attended the 2023 EMBL Cancer Genomics Conference in at the EMBL Advanced Training Centre in Heidelberg. During the event, we participated with 5 different posters, among which the poster of Arne Claeys earned the prestigious poster award! The diverse array of speakers and posters that provided state-of-the-art and often unpublished insights, gave us valuable new ideas and inspiration to apply in our own research.
Nov 15-17, 2023
Twenty-five percent of primary and metastatic tumors have evaded the immune system
Recent work from the Cuppen lab demonstrated that genetic immune escape is present in minimally 25% of tumors and loss of the HLA allele is the main mechanism. Prof. Jimmy Van den Eynden put these results into perspective in a Nature Genetics News and Views article.
May 10, 2023
HLA affinity-based selection signals are easy misinterpreted
In a Letter to The Editor of Cancer Research we demonstrated that previously perceived immunoediting signals are false.
Our main concerns:
- When neoantigen predictions are solely based on HLA affinities, the very low prediction accuracy makes every immunoediting signal extremely unlikely.
- Proteins translated from non-expressed genes have stronger average HLA affinities. This is not selection but simple biochemistry!
- Naïve data filtering = asking for problems. When only 10% of mutations are neoantigenic, removing samples without these mutations is problematic in tumors with low TMB.
Mar 15, 2023
Dr. Joachim Siaw awarded CRIG Proof-Of-Concept grant
Congratulations to Dr. Joachim Siaw for receiving the CRIG Young Investigator Proof-of-Concept Project Grant for his research project. This will allow him to investigate the therapeutic efficacy of RUVBL1/2 inhibition in neuroblastoma mice models and determine the spatial signaling dynamics in the tumor microenvironment.
March 24, 2023
Lab BBQ 2022
This September, Jimmy treated the lab to the yearly lab BBQ at his home.
Sep 2, 2022