Computational Cancer Genomics and Tumour Evolution

Van den Eynden lab

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In the lab, we are studying human carcinogenesis, mainly using computational approaches. Our lab has a double focus: tumor evolution and ALK signaling.

We are studying different phases of tumor evolution (healthy tissues, primary tumors, metastatic tumors …), mainly based on somatic mutation patterns. Somatic mutations are small DNA errors that accumulate during lifetime, eventually resulting in the generation of a malignant tumor. Because some of these mutations are under strong evolutionary pressure, studying their patterns has the potential to identify new cancer genes, indicate specific cancer vulnerabilities or unveil fundamental processes that occurred during tumor evolution like tumor-immune interactions, the development of treatment resistance or metastatic behavior.

Our lab also has a special interest in ALK signaling in neuroblastoma and other tumors where ALK alterations have been described as genomic driving events. The aim of our ALK research is to identify new therapeutic targets in these cancers.


  Jan 11, 2024

Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN

Jonatan L Gabre, Peter Merseburger, Arne Claeys, Joachim Siaw, Sarah-Lee Bekaert, Frank Speleman, Bengt Hallberg, Ruth H Palmer and Jimmy Van den Eynden


  May 09, 2023

Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data

Arne Claeys, Peter Merseburger, Jasper Staut, Kathleen Marchal and Jimmy Van den Eynden


  Mar 15, 2023

Quantification of Neoantigen-Mediated Immunoediting in Cancer Evolution

Arne Claeys, Jimmy Van den Eynden


  Feb 15, 2023

ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression

Tzu-Po Chuang, Wei-Yun Lai, Jonatan Gabre, Dan E. Lind, Ganesh Umapathy, Abdulmalik A. Bokhari, Bengt Bergman, Linnea Kristenson, Fredrik B. Thorén, Anh Le, Robert C. Doebele, Jimmy Van den Eynden, Ruth H. Palmer and Bengt Hallberg