Mutant clones in normal tissues
Background
Somatic mutations are small DNA errors that accumulate in the genome of ageing cells. These mutations sporadically result in a cellular growth advantage, especially when they occur in cancer genes. The sequential accumulation of these so-called driver mutations eventually leads to the formation of malignant tumors. Recent evidence suggests that they also underlie micro-clone formation in multiple histologically normal epithelial tissues, providing new insights in early human carcinogenesis.
What we do
We aim to characterize the somatic mutational landscape of the human body using post-mortem tissues obtained from clinically well-annotated whole-body donors, using different DNA and RNA sequencing approaches.
Who is involved
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Research output
Jan 5, 2024
Jan 6, 2023
Nederlandse Anatomen Vereniging conference 2023
The potential of whole-body donors for understanding early tumor evolution - Tom Luijts
Jun 20, 2022
A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues
Tom Luijts, Kerryn Elliott, Joachim Siaw, Joris Van de Velde, Elien Beyls, Arne Claeys, Tim Lammens, Erik Larsson, Wouter Willaert, Anne Vral and Jimmy Van den Eynden
May 23, 2022
CRIG Oncopoint Symposium 2022: a festive edition
A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in histologically healthy tissues - Tom Luijts