Computational Cancer Genomics and Tumour Evolution

Van den Eynden lab

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Our Research

In the lab, we are studying human carcinogenesis, mainly using computational approaches. Our lab has a double focus: tumor evolution and ALK signaling.

We are studying different phases of tumor evolution (healthy tissues, primary tumors, metastatic tumors …), mainly based on somatic mutation patterns. Somatic mutations are small DNA errors that accumulate during lifetime, eventually resulting in the generation of a malignant tumor. Because some of these mutations are under strong evolutionary pressure, studying their patterns has the potential to identify new cancer genes, indicate specific cancer vulnerabilities or unveil fundamental processes that occurred during tumor evolution like tumor-immune interactions, the development of treatment resistance or metastatic behavior.

Our lab also has a special interest in ALK signaling in neuroblastoma and other tumors where ALK alterations have been described as genomic driving events. The aim of our ALK research is to identify new therapeutic targets in these cancers.

Our Team

Latest publications


  May 09, 2023

Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data

Arne Claeys, Peter Merseburger, Jasper Staut, Kathleen Marchal and Jimmy Van den Eynden


  Mar 15, 2023

Quantification of Neoantigen-Mediated Immunoediting in Cancer Evolution

Arne Claeys, Jimmy Van den Eynden


  Feb 15, 2023

ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression

Tzu-Po Chuang, Wei-Yun Lai, Jonatan Gabre, Dan E. Lind, Ganesh Umapathy, Abdulmalik A. Bokhari, Bengt Bergman, Linnea Kristenson, Fredrik B. Thorén, Anh Le, Robert C. Doebele, Jimmy Van den Eynden, Ruth H. Palmer and Bengt Hallberg


  Jul 24, 2022

Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC

A.A. Bokhari, W-Y. Lai, A.T. Le, Jonatan Gabre, T-P. Chuang, S. Fransson, B. Bergman, A. Djos, N. Chen, T. Martinsson, Jimmy Van den Eynden, R.C. Doebele, R.H. Palmer, B. Hallberg and G. Umapathy


  Jun 20, 2022

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

Tom Luijts, Kerryn Elliott, Joachim Siaw, Joris Van de Velde, Elien Beyls, Arne Claeys, Tim Lammens, Erik Larsson, Wouter Willaert, Anne Vral and Jimmy Van den Eynden