Computational Cancer Genomics and Tumour Evolution

Van den Eynden lab

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Our Research

In the lab, we are studying human carcinogenesis, mainly using computational approaches. Our lab has a double focus: tumor evolution and ALK signaling.

We are studying different phases of tumor evolution (healthy tissues, primary tumors, metastatic tumors …), mainly based on somatic mutation patterns. Somatic mutations are small DNA errors that accumulate during lifetime, eventually resulting in the generation of a malignant tumor. Because some of these mutations are under strong evolutionary pressure, studying their patterns has the potential to identify new cancer genes, indicate specific cancer vulnerabilities or unveil fundamental processes that occurred during tumor evolution like tumor-immune interactions, the development of treatment resistance or metastatic behavior.

Our lab also has a special interest in ALK signaling in neuroblastoma and other tumors where ALK alterations have been described as genomic driving events. The aim of our ALK research is to identify new therapeutic targets in these cancers.

Our Team

Latest publications

Article

  Feb 15, 2023

ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression

Tzu-Po Chuang, Wei-Yun Lai, Jonatan Gabre, Dan E. Lind, Ganesh Umapathy, Abdulmalik A. Bokhari, Bengt Bergman, Linnea Kristenson, Fredrik B. Thorén, Anh Le, Robert C. Doebele, Jimmy Van den Eynden, Ruth H. Palmer and Bengt Hallberg

Article

  Jul 24, 2022

Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC

A.A. Bokhari, W-Y. Lai, A.T. Le, Jonatan Gabre, T-P. Chuang, S. Fransson, B. Bergman, A. Djos, N. Chen, T. Martinsson, Jimmy Van den Eynden, R.C. Doebele, R.H. Palmer, B. Hallberg and G. Umapathy

Article

  Jun 20, 2022

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

Tom Luijts, Kerryn Elliott, Joachim Siaw, Joris Van de Velde, Elien Beyls, Arne Claeys, Tim Lammens, Erik Larsson, Wouter Willaert, Anne Vral and Jimmy Van den Eynden

Article

  Nov 24, 2021

ATR inhibition enables complete tumour regression in ALK-driven NB mouse models

Joanna Szydzik, Dan E. Lind, Badrul Arefin, Yeshwant Kurhe, Ganesh Umapathy, Joachim Siaw, Arne Claeys, Jonatan Gabre, Jimmy Van den Eynden, Bengt Hallberg and Ruth H. Palmer

Article

  Apr 15, 2021

Loss of RET promotes mesenchymal identity in neuroblastoma cells

Joachim T. Siaw, Jonatan Gabre, Ezgi Uçkun, Marc Vigny, Wancun Zhang, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer and Jikui Guan

Article

  Feb 8, 2021

Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals

Arne Claeys, Tom Luijts, Kathleen Marchal and Jimmy Van den Eynden